WLN-CO.W.40.1Determination of different compounds by using LC-MSin-house method
Principle:The sample is, after acidification and addition of labeled internal standards, injected and analyzed by using high pressure liquid chromatography and accurate mass mass-selective detection. The surface ofthe peaks in the chromatogram is a measure of the concentration.
Determination:Medicins, LC/MS (2)
Performance characteristics:
Matrices qualified by the Dutch RvA (flexible scope):Drinking water, Groundwater, Surface water
Reporting limit:0.01 - 1 μg/l, parameter and matrix dependent
Measurement uncertainty:70%
Sustainability:6 days
Sampling bottle:Glass , brown , 100 ml (fill up to the neck of the bottle)
Parameters:
(RL = 0.01 μg/l)atorvastatin (not accreditated); bisoprolol; clofibric acid; cyclophosphamide; Enalapril; fenofibrate; fenofibrate related compound A; ifosfamide; indomethacin; primidone; tiamulin; sulfadiazine (not accreditated); antipyrine (not accreditated)
(RL = 0.02 μg/l)clofibrate; fluoxetine; furosemide (not accreditated); gemfibrozil; theophylline
(RL = 0.05 μg/l)lincomycine; tramadol
(RL = 0.1 μg/l)chloramphenicol; losartan; sulfaquinoxaline (not accreditated)
(RL = 0.2 μg/l)bezafibrate; paroxetine
(RL = 1 μg/l)pravastatin (not accreditated)
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