WLN-CO.W.40.1Determination of different compounds by using LC-MSin-house method
Principle:The sample is, after acidification and addition of labeled internal standards, injected and analyzed by using high pressure liquid chromatography and accurate mass mass-selective detection. The surface ofthe peaks in the chromatogram is a measure of the concentration.
Determination:Medicines, LC/MS
Performance characteristics:
Reporting limit:0.01 - 0.05 μg/l, parameter and matrix dependent
Measurement uncertainty:70%
Sustainability:6 days
Sampling bottle:Glass , brown , 100 ml (fill up to the neck of the bottle)
Parameters:
(RL = 0.01 μg/l)carbamazepine; clarithromycin; metoprolol; propranolol; sotalol; sulfametoxazole; trimethoprim; amisulpride (not accreditated); citalopram (not accreditated); venlafaxine (not accreditated); 1,2,3-benzotriazole; @4+5-methylbenzotriazol
(RL = 0.02 μg/l)diclofenac; gabapentine; irbesartan; furosemide (not accreditated); candesartan (not accreditated)
(RL = 0.05 μg/l)hydrochlorothiazide; azitromycine (not accreditated)
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